台北人工生殖中心
李新揚 醫學博士
專家簡介：
- 專精不孕症治療、試管嬰兒、人工生殖技術及人工授精。
- 對於胚胎著床之機轉、人工生殖技術之突破、幹細胞於生殖醫學之應用有獨到心得及創新成果。
- 李醫師博士論文專文研究胚胎著床機轉，榮獲婦產科醫學會最佳論文獎。
- 發表「超友善高成功率試管嬰兒療程」論文並刊登於知名國際期刊Reproductive Biology and Endocrinology
- 試管嬰兒成功案例達8000例。
治療優勢：
- 獨創「超友善高成功率試管嬰兒療程」，總共只須打2~5針，回診一次即可取卵，取卵數多，創高成功率，降低卵巢過度刺激症候群發生率，顛覆傳統療程必須施打10~30針才能取得的成果。
- 「子宮輕刮術」刺激間質幹細胞分泌增加懷孕機率，人工生殖成功率提升1.6倍。
- 人工生殖團隊診療無精蟲症病患的試管嬰兒療程技術領先亞洲，已累積許多成功案例。
- 所帶領人工生殖團隊擁有10~20年以上胚胎操作經驗，其胚胎培養及胚胎切片行染色體基因診斷PGD/PGS技術首屈一指，提高著床率，降低流產風險及嬰兒健康風險，團隊並有文章榮登生殖醫學最知名期刊「人類生殖」。
- 高品質的無塵無毒胚胎室及最先進的胚胎縮時攝影培養系統。
學歷
美國Johns Hopkins 大學醫學院博士後研究
國立陽明大學臨床醫學研究所博士
國立陽明大學醫學系學士
經歷
中華民國生育醫學會理事長
台北榮總婦產部生殖內分泌科主任
國立陽明大學醫學系婦產學科副教授
國立陽明大學解剖暨細胞生物學研究所副教授
專長及研究領域
專長：不孕症、試管嬰兒、人工生殖技術、人工授精
研究領域：胚胎著床之機轉、人工生殖技術之突破、幹細胞於生殖醫學之應用
學術論文
- Kuan-chong chao, Chi-ching Chang, Hsin-Yang Li, Ming-shyen Yen, Heung-Tat
Ng. Identification of human papillomavirus type 16 DNA in cervical
squamous intraepithelial neoplasm by polymerase chain reaction. J. OB/GYN.
ROC. 34:127-130, 1995.
- Kuan-chong chao, Heung-Tat Ng, Ming-shyen Yen, Hsin-Yang Li, Chi-ching
Chang. The effect of granulocyte colony-stimulating factor on the
growth of human ovarian carcinoma cells in vitro. J. OB/GYN. ROC. 35:11-
18, 1996.
- Hsin-Yang Li, Kuan-Chong Chao, Heung-Tat Ng. Metastatic ovarian cancer of
unknown origin J. Gynecol. Oncol. ROC. 2:8-12, 1996.
- Hsin-Yang Li, Hwa-Shyi Wu, Long-Mou Chiu, Shein-Pin Shuai, Heung-Tat Ng.
Adenosquamous cell carcinoma of the cervix: a clinical analysis of 28 cases. J.
Gynecol. Oncol. ROC. 2:27-31, 1996.
- Hsing-Yang Li, Jeng-Hsiu Hung. Application of ultrasound to screening of ovarian
cancer. J. Gynecol. Oncol. ROC. 1:13-15, 1997.
- Hsin-Yang Li, Ken-Jen Yu. Leiomyosarcoma of uterus: a clinical analysis of 17
cases. J. Gynecol. Oncol. ROC. 1:24-27, 1997.
- Hsin-Yang Li, Teng-Sheng Chang. Vaginal fluid creatinine, human chorionic
gonadotropin, and alpha-fetoprotein levels for detecting premature rupture of
membranes. Chi. Med. J. 63:686-690, 2000.
- Hsin-Yang Li, Sheng-Ping Chang, Chiou-Chung Yuan, Hsiang-Tai Chao, Heung-
Tat Ng, Yen-Jen Sung. Nitric oxide induces extensive apoptosis in endometrial
epithelial cells in the presence of progesterone: involvement of mitogen-activated
protein kinase pathways. Mol. Hum. Reprod. 7:755-763, 2001.
- Hsin-Yang Li, Sheng-Ping Chang, Chiou-Chung Yuan, Hsiang-Tai Chao, Heung-
Tat Ng, Yen-Jen Sung. Establishment of an efficient method to quantify embryo
attachment to endometrial epithelial cell monolayers. In Vitro Cell. Dev. Biol.-
Animal. 38:505-511, 2002.
- Hsin-Yang Li, Sheng-Ping Chang, Chiou-Chung Yuan, Hsiang-Tai Chao, Heung-
Tat Ng, Yen-Jen Sung. Induction of p38 mitogen-activated protein kinase-mediated apoptosis is involved in outgrowth of trophoblast cells on endometrial epithelial cells in a model of human trophoblast-endometrial interactions. Biol. Reprod. 69:1515-1524, 2003.
- Kuan-Hao Tsui, Ling-Yun Chen, Miawh-Lirng Shieh, Sheng-Ping Chang, Chiou-Chung Yuan and Hsin-Yang Li (correspondence author). Interleukin-8 can stimulate progesterone secretion from a human trophoblast cell line, BEWO. In Vitro Cell. Dev. Biol.-Animal. 40:331-336, 2004.
- Dau-Ming Niu, Jing-Ying Huang, Hsin-Yang Li, Kai-Ming Liu, Shih-TingWang,
Yann-Jang Chen, Toru Udaka, Kosuke Izumi, and Kenjiro Kosaki. Paternal gonadal mosaicism of NIPBL mutation in a father of siblings with Cornelia de Lange syndrome. Prenat. Diagn. 26:1054-1057, 2006.
- Hsin-Yang Li, Jin-Te Shen, Sheng-Ping Chang, Wei-Lun Hsu, and Yen-Jen Sung. Calcitonin promotes outgrowth of trophoblast cells on endometrial epithelial cells: involvement of calcium mobilization and protein kinase C activation. Placenta 29:20-29, 2008.
- Wei-Lun Hsu, Ya-Hui Chen, Kuan-Chong Chao, Sheng-Ping Chang, Kuan-Hao Tsui, Hsin-Yang Li (correspondence author), and Yen-Jen Sung (correspondence author). Anti-Fas activating antibody enhances trophoblast outgrowth on endometrial epithelial cells by induction of p38 MAPK/JNK-mediated apoptosis. Placenta 29:338-346, 2008.
- Lily Wen, Li-Hsun Chen, Hsin-Yang Li (correspondence author), Sheng-Ping Chang, Chen-Yi Liao, Kuan-Hao Tsui, Yen-Jen Sung, and Kuan-Chong Chao. Roles of estrogen and progesterone in endometrial hemodynamics and vascular endothelial growth factor production. J. Chin. Med. Assoc. 72:188-193, 2009.
- Jen-Yu Tseng, Ming-Jie Yang, Chih-Chun Yang, Kuan-Chong Chao, and Hsin-Yang Li (correspondence author). Acute cholecystitis during pregnancy: What is the best approach? Taiwan. J. Obstet. Gynecol. 48:305-307, 2009.
- Chung-Lan Kao (correspondence author), Lung-Ko Tai, Shih-Hwa Chiou, Yi-Jen Chen, Kung-Shun Lee, Shih-Jie Chou, Yuh-Lih Chang, Chia-Ming Chang, Shih-Jen Chen, Hung-Hai Ku, and Hsin-Yang Li (correspondence author). Resveratrol promotes osteogenic differentiation and protects against dexamethasone damage in murine induced pluripotent stem cells. Stem Cells Dev. 19:247-258, 2010.
18..Hsin-Yang Li, Yi-Jen Chen, Shih-Jen Chen, Chung-Lan Kao, Ling-Ming Tseng, Wen-Liang Lo, Chia-Ming Chang, Der-Ming Yang, Hung-Hai Ku, Nae-Fang Twu, Shih-Hwa Chiou, and Yuh-Lih Chang. Induction of insulin-producing cells derived from endometrial mesenchymal stem-like cells. J. Pharmacol. Exp. Ther. 335:817-29, 2010.
- Shih-Jen Chen, Chia-Ming Chang, Shen-Kou Tsai, Yuh-Lih Chang, Shiang-Suo
Huang, Lung-Kuo Tai, Hsin-Yang Li, Yu-Chih Chen, Yi-Jen Chen, Hung-Hai Ku, and Shih-Hwa Chiou. Functional improvement of focal cerebral ischemia injury by subdural transplantation of induced pluripotent stem cells with fibrin glue. Stem Cells Dev. 19:1757-1767, 2010.
- Yi-Jen Chen, Hsin-Yang Li, Lung-Kuo Tai, Yuh-Lih Chang, Ming-Shyen Yen,
Chiou-Chung Yuan, Chia-Ming Chang, Kai-Hsi Lu, and Shih-Hwa Chiou. Suppression of migratory/invasive ability and induction of apoptosis in adenomyosis-derived mesenchymal stem cells by cyclooxygenase-2 inhibitors. Fertil. Steril. 94:1972-1979, 2010.
- Yi-Jen Chen, Hsin-Yang Li, Chi-Hung Huang, Nae-Fang Twu, Ming-Shyen Yen, Peng-Hui Wang, Teh-Ying Chou, Yen-Ni Liu, Kuan-Chong Chao and Muh-Hwa Yang. Oestrogen-induced epithelial–mesenchymal transition of endometrial epithelial cells contributes to the development of adenomyosis. J. Pathol. 222:261-270, 2010.
- Li-Hsin Chen, Guang-Yuh Chiou, Yi-Wei Chen, Hsin-Yang Li, and Shih-Hwa Chiou. MicroRNA and aging: a novel modulator in regulating the aging network. Ageing Res. Rev. 9 Suppl 1:S59-66, 2010.
- Tu-Lai Yew*, Yeh-Ting Hung*, Hsin-Yang Li* (equal first author), Hsin-Wei Chen, Ling-Lan Chen, Kuo-Shu Tsai, Shih-Hwa Chiou, Kuan-Chong Chao, Tung-Fu Huang, Hen-Li Chen, and Shih-Chieh Hung. Enhancement of wound healing by human multipotent stromal cell conditioned medium: the paracrine factors and p38MAPK activation. Cell Transplant. 20:693-706, 2011.
- Hsin-Yang Li, Chen-Yi Liao, Kun-Hsiung Lee, Hung-Chi Chang, Yi-Jen Chen, Kuan-Chong Chao, Sheng-Ping Chang, Hsin-Yi Cheng, Chia-Ming Chang, Yuh-Lih Chang, Shih-Chieh Hung, Yen-Jen Sung (correspondence author), and Shih-Hwa Chiou (correspondence author). Collagen IV significantly enhances migration and transplantation of embryonic stem cells: involvement of a2b1 integrin-mediated actin remodeling. Cell Transplant. 20:893-907, 2011.
- Kuan-Hao Tsui, Peng-Hui Wang, Chia-Kai Chen, Yi-Jen Chen, Shih-Hwa Chiou, Yen-Jen Sung, and Hsin-Yang Li (correspondence author). Non-classical estrogen receptor actions on human dermal fibroblasts. Taiwan. J. Obstet. Gynecol. 50:474-478, 2011.
- Shih-Hwa Chiou, Shih-Jen Chen*, Yuh-Lih Chang*, Yu-Chih Chen*, Hsin-Yang Li* (equal second author), Dow-Tien Chen, Hsin-Hui Wang, Chia-Ming Chang, Yi-Jen Chen, and Hung-Hai Ku. MafA promotes the reprogramming of placenta-derived multipotent stem cells into pancreatic islets-like and insulin-positive cells. Cell. Mol. Med. 15:612-624, 2011.
- Kuang-Yao Yang, Hsin-Chin Shih, Chorng-Kuang How, Cheng-Yu Chen, Han-Shui Hsu, Ching-Wen Yang, Yu-Chin Lee, Reury-Perng Perng, Hsin-Yang Li, Chia-Ming Chang, Chung-Yuan Mou, and Shih-Hwa Chiou. Intravenous delivery of induced pluripotent stem cells attenuates endotoxin-induced acute lung injury in mice. Chest140:1243-1253, 2011.
- Hsin-Yang Li, Yueh Chien, Yi-Jen Chen, Szu-Fu Chen, Yuh-Lih Chang, Chih-Hung Chiang, Shaw-Yeu Jeng, Chia-Ming Chang, Mong-Lien Wang, Liang-Kung Chen, Shuen-Iu Hung, Teh-Ia Huo, Shou-Dong Lee, and Shih-Hwa Chiou. Reprogramming induced pluripotent stem cells in the absence of c-Myc for differentiation into hepatocyte-like cells. Biomaterials 32:5994-6005, 2011.
- Kuan-Chong Chao, Chi-Hong Ho, Wen-Yuann Shyong, Chen-Yu Huang, Shu-Chuan Tsai, Hsin-Yi Cheng, Luoh-Chyi Chou, Chih-Hsiu Lin, and Hsin-Yang Li. Anti-Mullerian hormone serum level as a predictive marker of ovarian function in Taiwanese women. Chin. Med. Assoc. 75:70-74, 2012.
- Yuh-Lih Chang, Shih-Jen Chen, Cheng-Chia Yu, Dah-Ching Ding, Yi-Jen Chen, Hung-Hai Ku, Chin-Po Lin, Shih-Chieh Hung, Kun-Hsiung Lee, Liang-Kung Chen, Chung-Lan Kao, Jhi-Joung Wang, Chuan-Chih Hsu, Hsin-Yang Li (correspondence author), and Shih-Hwa Chiou (correspondence author). Docosahexaenoic acid promotes dopaminergic differentiation in induced pluripotent stem cells and inhibits teratoma formation in rats with parkinson-like pathology. Cell Transplant. 21:313-332, 2012.
- Hua-Ming Chang, Yi-Wen Liao, Chih-Hung Chiang, Yi-Jen Chen, Ying-Hsiu Lai, Yuh-Lih Chang, Hen-Li Chen, Shaw-Yeu Jeng, Jung-Hung Hsieh, Chi-Hsien Peng, Hsin-Yang Li, Yueh Chien, Szu-Yu Chen, Liang-Kung Chen, and Teh-Ia Huo. Improvement of carbon tetrachloride-induced acute hepatic failure by transplantation of induced pluripotent stem cells without reprogramming factor c-Myc. J. Mol. Sci. 13:3598-3617, 2012.
- Yi-Jen Chen, Ying-Jay Liou, Chia-Ming Chang, Hsin-Yang Li, Chih-Yao Chen, Nae-Fang Twu, Ming-Shyen Yen, Yuh-Lih Chang, Chi-Hsien Peng, Shih-Hwa Chiou, Chih-Ping Chen, and Kuan-Chong Chao. Reprogramming human endometrial fibroblast into induced pluripotent stem cells. J. Obstet. Gynecol. 51:35-42, 2012.
- Yi-Wen Chang, Chia-Ming Chang, Pi-Lin Sung, Ming-Jie Yang, Wai Hou Li, Hsin-Yang Li, Ling-Chao Chen, Ling-Yi Cheng, Yu-Ling Lai, Yung-Yung Cheng, Wen-Hsun Chang, Kuan-Chong Chao, Peng-Hui Wang. An overview of a 30-year experience with amniocentesis in a single tertiary medical center in Taiwan. J. Obstet. Gynecol. 51:206-211, 2012.
- Yi-Jen Chen, Hua-Hsi Wu, Wan-Ting Liau, Chang-Youh Tsai, Hsiao-Wen Tsai, M.D., Kuan-Chong Chao, Yen-Jen Sung, and Hsin-Yang Li (correspondence author). A tumor necrosis factor-α inhibitor reduces the embryotoxic effects of endometriotic peritoneal fluid. Fertil. Steril. 100:1476-1485, 2013.
- Cheng-Kuan Lin, Kuo-Chang Wen, Pi-Lin Sung, Shih-Cheih Lin, Chiung-Ru Lai, Kuan-Chong Chao, Ming-Shyen Yen, Chia-Chien Chen, Hsin-Yang Li, and Loy-Lan Too. Heterotopic triplet pregnancy with an intrauterine, a tubal, and a cervical gestation following in vitro fertilization and embryo transfer. J. Obstet. Gynecol.52:287-289, 2013.
- Tze-Sing Huang, Yi-Jen Chen, Teh-Ying Chou, Chih-Yao Chen, Hsin-Yang Li, Ben-Shian Huang, Hsiao-Wen Tsai, Hsin-Yi Lan, Cheng-Hsuan Chang, Nae-Fang Twu, Ming-Shyen Yen, Peng-Hui Wang, Kuan-Chong Chao, Chun-Chung Lee, and Muh-Hwa Yang. Oestrogen-induced angiogenesis promotes adenomyosis by activating the Slug-VEGF axis in endometrial epithelial cells. Cell. Mol. Med. 18:1358-1371, 2014.
- Yun-Ching Chang, Wan-Chun Li, Nae-Fang Twu, Hsin-Yang Li, Wen-Liang Lo, Yuh-Lih Chang, Yi-Yen Lee, Chun-Fu Lin, Yang-Hsin Shih, Ming-Teh Chen. Induction of dental pulp-derived induced pluripotent stem cells in the absence of c-Myc for differentiation into neuron-like cells. Chin. Med. Assoc. 77:618-625, 2014.
- Wei-Hsiu Liu, Yuh-Lih Chang, Wen-Liang Lo, Hsin-Yang Li, Chia-Wei Hsiao, Chi-Hsien Peng, Shih-Hwa Chiou, Hsin-I Ma, and Shih-Jen Chen. Human induced pluripotent stem cell and nanotechnology-based therapeutics. Cell Transplant.24:2185-2195, 2015.
- Wei-Fang Chang, Jie Xu, Chia-Chun Chang, Shang-Hsun Yang, Hsin-Yang Li, Hsiu Mei Hsieh-Li, Mong-Hsun Tsai, Shinn-Chih Wu, Winston T. K. Cheng, Ji-Long Liu, and Li-Ying Sung. SMN is required for the maintenance of embryonic stem cells and neuronal differentiation in mice. Brain Struct. Funct. 220:1539-1553.
- Yueh Chien, Yuh-Lih Chang, Hsin-Yang Li, Mikael Larsson, Wai-Wah Wu, Chian-Shiu Chien, Chien-Ying Wang, Pen-Yuan Chu, Kuan-Hsuan Chen, Wen-Liang Lo, Shih-Hwa Chiou, Yuan-Tzu Lan, Teh-Ia Huo, Shou-Dong Lee, and Pin-I Huang. Synergistic effects of carboxymethyl-hexanoyl chitosan, cationic polyurethane-short branch PEI in miR122 gene delivery: Accelerated differentiation of iPSCs into mature hepatocyte-like cells and improved stem cell therapy in a hepatic failure model. Acta Biomater. 13:228-244, 2015.
- Bo-Hua Jiang, Wei-Lien Tseng, Hsin-Yang Li, Mong-Lien Wang, Yuh-Lih Chang, Yen-Jen Sung, and Shih-Hwa Chiou. Poly(ADP-ribose) polymerase 1: cellular pluripotency, reprogramming, and tumorogenesis. J. Mol. Sci. 16:15531-15545, 2015.
- Bo-Hus Jiang, Wei-Yi Chen, Hsin-Yang Li, Yueh Chien, Wei-Chao Chang, Pei-Chen Hsieh, Ping Wu, Chieh-Yu Chen, Hui-Yung Song, Chian-Shiu Chien, Yen-Jen Sung, and Shih-Hwa Chiou. CHD1L regulated PARP1-driven pluripotency and chromatin remodeling during the early-stage cell reprogramming. Stem Cells33:2961-2972, 2015.
- Ping-Hsing Tsai, Yueh Chien, Jen-Hua Chuang, Shih-Jie Chou, Chian-Hsu Chien, Ying-Hsiu Lai, Hsin-Yang Li, Yu-Lin Ko, Yuh-Lih Chang, Chen-Ying Wang, Yung-Yang Liu, Hsin-Chen Lee, Chang-Hao Yang, Ting-Fen Tsai, Yi-Yen Lee, and Shih-Hwa Chiou. Dysregulation of mitochondrial functions and osteogenic differentiation in Cisd2-deficient murine induced pluripotent stem cells. Stem Cells Dev. 24:2561-2576, 2015.
- Chih-Hung Chiang, Wai-Wah Wu, Hsin-Yang Li, Yueh Chien, Cho-Chin Sun, Chi-Hsien Peng, Alex Tong-Long Lin, Chi-Shuan Huang, Ying-Hsiu Lai, Shih-Hwa Chiou, Shuen-Iu Hung, Yuh-Lih Chang, Yuan-Tzu Lan, Dean-Mo Liu, Chian-Shiu Chien, Teh-Ia Huo, Shou-Dong Lee, Chien-Ying Wang. Enhanced antioxidant capacity of dental pulp-derived iPSC-differentiated hepatocytes and liver regeneration by injectable HGF-releasing hydrogel in fulminant hepatic failure. Cell Transplant. 24:541-559, 2015.
- Ming-Jie Yang , Jen-Yu Tseng, Chih-Yao Chen, and Hsin-Yang Li. Delivery of double singleton pregnancies in a woman with a double uterus, double cervix, and complete septate vagina. Chin. Med. Assoc. 78:746-748, 2015.
- Chen-Yu Huang, Miawh-Lirng Shieh, and Hsin-Yang Li (correspondence author). The benefit of individualized low-dose hCG support for high responders in GnRHa-triggered IVF/ICSI cycles. Chin. Med. Assoc. 79:387-393, 2016.
- Yueh Chien, Chian-Shiu Chien, Huai-Chih Chiang, Wei-Lin Huang, Shih-Jie Chou, Wei-Chao Chang, Yuh-Lih Chang, Hsin-Bang Leu, Kuan-Hsuan Chen, Kang-Ling Wang, Ying-Hsiu Lai, Yung-Yang Liu, Kai-Hsi Lu, Hsin-Yang Li, Yen-Jen Sung, Yuh-Jyh Jong, Yann-Jang Chen, Chung-Hsuan Chen, and Wen-Chung Yu. Interleukin-18 deteriorates Fabry cardiomyopathy and contributes to the development of left ventricular hypertrophy in Fabry patients with GLA IVS4+919 G>A mutation. Oncotarget 7:87161-87179, 2016.
- Ben-Shian Huang, Muh-Hwa Yang, Peng-Hui Wang, Hsin-Yang Li, Teh-Ying Chou and Yi-Jen Chen. Oestrogen-induced angiogenesis and implantation contribute to the development of parasitic myomas after laparoscopic morcellation. Biol. Endocrinol. 14:64, 2016.
- Nai-Chi Chiu, Chi-Hong Ho, Shu-Huei Shen, Yu-Chuan Tsuei, Kang-Lung Lee, Chen-Yu Huang, Hsin-Yang Li, and Tzeng-Ji Chen. Impact of hysterosalpingography after operative treatment for ectopic pregnancy in Taiwan: A 16-year Nationwide Population-Based Analysis. Medicine (Baltimore) 96:e7263, 2017.
- Ke-Hung Chien, Yuh-Lih Chang, Mong-Lien Wang, Jen-Hua Chuang, Ya-Chi Yang, Ming-Cheng Tai, Chien-Ying Wang, Yung-Yang Liu, Hsin-Yang Li, Jiang-Torng Chen, Shou-Yen Kao, Hen-Li Chen, and Wen-Liang Lo. Promoting induced pluripotent stem cell-driven biomineralization and periodontal regeneration in rats with maxillary-molar defects using injectable BMP-6 hydrogel. Rep. 8: 114, 2018.
- Chi-Hong Ho, Chen-Wei Lan, Chen-Yi Liao, Shih-Chieh Hung, Hsin-Yang Li, and Yen-Jen Sung. Mesenchymal stem cells and their conditioned medium can enhance the repair of uterine defects in a rat model. Chin. Med. Assoc. 81: 268-276, 2018.
- Chen-Yu Huang, Guan-Yeu Chen, Miawh-Lirng Shieh and Hsin-Yang Li (correspondence author). An extremely patient-friendly and efficient stimulation protocol for assisted reproductive technology in normal and high responders. Biol. Endocrinol.16:18, 2018.
